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However, combined sales growth for these three products was 29 per cent. Sales of the older respiratory products, Ventolin and Becotide, continued to decline in the face of generic competition. Anti-bacterials Anti-bacterial sales declined by six per cent mainly as a result of increased generic competition, particularly in the USA, for the older products Zinnat Ceftin, Fortum and Amoxil. The sales growth of Augmentin slowed to two per cent reflecting generic competition in Europe. US sales in this period were not impacted by generic Augmentin which was introduced in the USA in July. Augmentin ES extra strength ; , launched in the USA last year for the treatment of antibiotic resistant ear infections in children, now represents over 35 per cent of Augmentin's paediatric prescriptions. Additionally, GlaxoSmithKline anticipates the launch of an extra strength adult version, Augmentin XR extended release ; , in the USA where it is currently under review by the FDA. Anti-virals Global sales growth in anti-virals improved to 15 per cent compared with six per cent for the same period in 2001. Strong performance in all regions by GlaxoSmithKline's triple combination therapy, Trizivir, was the key driver of growth in the HIV AIDS franchise. In the USA, it is now the most frequently prescribed treatment for new HIV patients. Valtrex for herpes also reported strong sales growth of 29 per cent worldwide and 39 per cent in the USA, benefiting from its convenient once-daily dosing. Although sales of Zovirax improved in the USA, in other regions they declined as a result of switches to Valtrex and generic competition. Metabolic and gastro-intestinal Sales of GlaxoSmithKline's treatment for type 2 diabetes, Avandia, rose to 418 million assisted by increased prescription volume in the USA and strong growth in Europe and the Rest of the World. A further decline in sales of Zantac resulted from the ongoing impact of generic competition. Vaccines The Hepatitis portfolio showed growth of 11 per cent, reversing the trend shown in 2001. The main contributor to this was sales of Twinrix in the USA, where it was launched in 2001. The combination vaccine, Infanrix, for diphtheria, tetanus and pertussis whooping cough ; grew 10 per cent, driven by continuing success in the US market and the Rest of the World. The decline in Europe reflected the impact of a large tender contract in 2001 that has not been repeated in 2002. Oncology and emesis An 18 per cent sales growth in the oncology and emesis therapy area was fuelled by the continuing growth of Zofran, which is used to prevent nausea and vomiting associated with some cancer treatments and surgical procedures. Cardiovascular GlaxoSmithKline's marketing rights to Coreg are mainly in the USA where sales grew by 30 per cent to 132 million. Other therapeutic areas Sales of Relafen for arthritis fell significantly in all areas, as a result of further generic competition.
1st dam BEYOND DOUBT GB ; : 2 wins at 3 and placed 4 times; dam of 5 previous foals; 2 runners: Sure Sign GB ; 00 g. Selkirk USA : placed twice at 2 and 3, 2003. Duty Bound GB ; 01 f. Halling USA : 3-y-o unraced to date. Bila GB ; 02 f. Selkirk USA : 2-y-o unraced to date. Shine Bright GB ; 03 f. Fantastic Light USA , yearling. 2nd dam Highbrow: winner at 2, placed 6 times inc. 2nd Ribblesdale S., Gr.2, Glorious S., L., 4th Park Hill S., Gr.2 and Lancashire Oaks, Gr.3; dam of 6 winners inc.: BLUEPRINT IRE ; c. by Generous IRE : 9 wins at home and in U.S.A. and 367, 800 inc. Jockey Club S., Gr.2, San Luis Rey H., Gr.2, Sunset H., Gr.2, 2nd September S., Gr.3, 3rd San Juan Capistrano Invitational H., Gr.1; sire. FAIRY GODMOTHER GB ; f. by Fairy King USA : 2 wins at 3 and 27, 042 inc. Ballymacoll Stud S., L., placed 2nd Earl of Sefton S., Gr.3; broodmare. 3rd dam HIGHCLERE by Queen's Hussar ; : 3 wins at 2 and 3 at home and in France and 155, 225 inc. 1000 Guineas S., Gr.1 and Prix de Diane de Revlon, Gr.1, placed 2nd King George VI & Queen Elizabeth S., Gr.1; dam of 7 winners inc.: HEIGHT OF FASHION FR ; : 5 wins at 2 and 3 and 69, 815 inc. Princess of Wales's S., Gr.2; dam of 8 winners inc.: NAYEF USA ; : 9 wins to 2003 and 2, 359, 713 inc. Juddmonte International S., Gr.1, Dubai Champion S., Gr.1 and Sheema Classic, Gr.1. NASHWAN USA ; : Champion 3yr old in England in 1989 9.5-11f. ; , 6 wins at 2 and 3, 793, 424 inc. Derby S., Gr.1, 2000 Guineas, Gr.1; sire. UNFUWAIN USA ; : 6 wins at 2 to inc. Jockey Club S., Gr.2 and Princess of Wales's S., Gr.2, 2nd King George VI & Queen Elizabeth S., Gr.1; sire. ALWASMI USA ; : 3 wins at home and U.S.A. inc. John Porter S., Gr.3; sire. MUKDDAAM USA ; : 3 wins and 62, 982 inc. Charmer Fred Archer S., L. SARAYIR USA ; : 3 wins at 2 and 3 inc. Pertemps Virginia Rated S. H., L. Wijdan USA ; : 2 wins, 2nd Pretty Polly S., L.; dam of ORIENTAL FASHION IRE ; 3 wins at 2 and 3 and 54, 270 inc. Premio Ribot, Gr.2 ; . MILFORD: 3 wins at 3 and 46, 109 inc. Princess of Wales's S., Gr.2; sire. Burghclere: winner at 3, 4th Ribblesdale S., Gr.2; dam of 6 winners inc.: WIND IN HER HAIR IRE ; : 3 wins at 3 and 4 at home and in Germany and 191, 389 inc. Aral-Pokal, Gr.1, 2nd Oaks S., Gr.1; dam of VEIL OF AVALON USA ; won De La Rose H., Gr.3, 3rd Winstar Galaxy S., Gr.2 ; . CAPO DI MONTE: 5 wins at home and in U.S.A. inc. Vineland H., Gr.3, 2nd Sun Chariot S., Gr.2; grandam of MAGIC MISSION GB ; 4 wins to 2003 in France and in U.S.A. inc. Royal Heroine S., Gr.3, 3rd Matriarch S., Gr.1 ; . Wily Trick USA ; : placed 4 times at 3; dam of 4 winners inc.: ELEGANT FASHION AUS ; : 8 wins to 2004 in Australia and in Hong Kong inc. Kewney S., Gr.2, Angus Armanasco S., Gr.2, 2nd Australian Oaks, Gr.1. Stabled in Barn G Box 21 and adalat.
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1. Wagstaff, A., Faulds, D., & Goa, K. 1994 ; . Aciclovir. Drugs 47, 153205. 2. Beutner, K. 1995 ; . Valaciclovir: a review of its antiviral activity, pharmacokinetic properties, and clinical efficacy. Antiviral Research 28, 28190. 3. Rolan, P. 1995 ; . Pharmacokinetics of new antiherpetic agents. Clinical Pharmacokinetics 29, 33340. 4. Acosta, E., & Fletcher, C. 1997 ; . Valaciclovir. Annals of Pharmacotherapy 31, 18591. 5. Perry, C. & Faulds, D. 1996 ; . Valaciclovir. Drugs 52, 75472. 6. Fletcher, C. & Bean, B. 1985 ; . Evaluation of oral aciclovir therapy. Drug Intelligence and Clinical Pharmacy 19, 51824. 7. De Miranda, P. & Blum, M. 1983 ; . Pharmacokinetics of aciclovir after intravenous and oral dosing. Journal of Antimicrobial Chemotherapy 12, Suppl. B, 2937. 8. Zovirax prescribing information 2001 ; . GlaxoSmithKline, Research Triangle Park, North Carolina, USA. 9. Krasny, H., deMiranda, P., Blum, M. et al. 1981 ; . Pharmacokinetics and bioavailability of aciclovir in the dog. Journal of Pharmacology and Experimental Therapeutics 261, 2818. 10. Bacon, T., Levin, M., Leary, J. et al. 2003 ; . Herpes simplex virus resistance to aciclovir and penciclovir after two decades of antiviral therapy. Clinical Microbiology Reviews 16, 11428. 11. Purifoy, D., Beauchamp, L., de Miranda, P. et al. 1993 ; . Review of research leading to new anti-herpesvirus agents in clinical development: valaciclovir hydrochloride and 882C, a specific agent for varicella. Journal of Medical Virology 41, Suppl. 1, 13945. 12. Beauchamp, L., Orr, G., de Miranda, P. et al. 1992 ; . Amino acid ester prodrugs of aciclovir. Antviral Chemistry and Chemotherapy 3, 15764. 13. De Vrueh, R., Smith, P. & Lee, C. 1998 ; . Transport of L-valine-aciclovir via the oligopeptide transporter in the human intestinal cell line, Caco-2. Journal of Pharmacology and Experimental Therapeutics 286, 116670. 14. Han, H., de Vreuh, R., Rhie, J. et al. 1998 ; . 5-amino acid esters of antiviral nucleosides, aciclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter. Pharmaceutical Research 15, 11549. 15. Han, H., Oh, D. & Amidon, G. 1998 ; . Cellular uptake mechanism of amino acid ester prodrugs in Caco-2 hPEPT1 cells overexpressing a human peptide transporter. Pharmaceutical Research 15, 13826. 16. Guo, A., Hu, P., Balimane, P. et al. 1999 ; . Interactions of a nonpeptidic drug, valaciclovir, with the human intestinal peptide transporter hPEPT1 ; expressed in a mammalian cell line. Journal of Pharmacology and Experimental Therapeutics 289, 44854. 17. Balimane, P., Tamai, I., Guo, A. et al. 1998 ; . Direct evidence for peptide transporter PepT1 ; -mediated uptake of a nonpeptide prodrug, valaciclovir. Biochemical and Biophysical Research Communications 250, 24651. 18. Ganapathy, M., Huang, W., Wang, H. et al. 1998 ; . Valaciclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2. Biochemical and Biophysical Research Communications 246, 4705.
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Piece of the outer coat of HSV-2 called a glycoprotein. This surface protein provokes the body's immune system to swing into action, dispatching antibodies that neutralize or kill the virus. The vaccine also has a chemical, called an adjuvant, "that turbocharges the immune response" by making it attack the virus more quickly, says Dr. Robert B. Belshe, director of the Center for Vaccine Development at Saint Louis University in Missouri, one of the sites where the new vaccine is being tested. Results were announced last year of two studies involving 2, 700 men and women whose regular sexual partners had genital herpes. Among women who had neither HSV-1 nor HSV2, the vaccine prevented disease symptoms in 73% and stopped viral transmission in 40%. It had no clear effect on women who were already infected with HSV-1 or on men. Scientists don't understand why this happened, says Stanberry. They speculate that in women, the presence of HSV-1 confers an immunity to the vaccine; and men don't respond as strongly to immune system stimulation. But even if the virus simply prevents an infected woman from developing symptoms which means the virus isn't shedding ; , it's possible that the spread of genital herpes and HIV could still be curbed. The new study, which is being done at 16 centers in the United States, including UCLA, will focus solely on those people who seem to respond to the vaccine -- women who are not infected with either type of virus -- to establish just how useful the vaccine may be. It will involve 7, 550 women between the ages of 18 and 30; volunteers will receive three injections over six months, with a follow-up after 20 months to determine whether the vaccine works. "If the vaccine proves effective, " says Belshe, "we'll target pre- adolescent girls to protect them before they're infected with either virus. Eventually, the herpes viruses will die out -just like polio." Herpes treatments There is no cure for herpes, but three oral medications, available by prescription, can treat HSV-2: acyclovir Zovirax ; , famciclovir Famvir ; and valacyclovir Valtrex ; . Each of these drugs can reduce the frequency of outbreaks and speed healing when symptoms appear. Studies have also shown that valacyclovir can reduce by 50% the risk of transmission of HSV-2 to a partner who does not have the virus and alesse and zovirax.
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Employees As of the Offering Circular Date, Carlsson Research has 33 employees corresponding to 30 full-time equivalents FTEs , of which seven hold Ph.D.'s. Carlsson Research employs medicinal chemists, combinatorial chemists, analytical chemists, computational chemists, pharmacologists, biologists, physicians, physicists, medical laboratory technicians and a research engineer. The chemistry unit has extensive experience in medicinal chemistry relating to CNS indications. State of the art computational chemistry tools are used to optimise the choice of compounds for new synthesis, and to investigate structure-activity relationships. The biology unit performs approximately 350 in vivo experiments each year, using an array of experimental models. The data collected in behavioural assays are processed and analysed using a sophisticated advanced, inhouse developed system yielding a detailed and precise characterisation of behavioural patterns. Furthermore, quality assessments are continuously performed on all in vivo data by the computational chemistry unit. The biological testing includes DMPK Drug Metabolism and Pharmacokinetics ; assessment, both in vivo and in vitro. Integrated into the biology unit is the computational biology and biostatistics unit, responsible for the analysis, integration and interpretation of in vivo biological data, including data collected in clinical studies. The computational biology and biostatistics unit has long-standing experience in the fields of exploratory, multivariate data analysis applied to biological data. The development unit is responsible for preclinical development, regulatory affairs as well as clinical research and development, for instance, cost of zovirax.
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Much as we do with rabies, it is important to assess the nature of possible exposure to anthrax of any concerned person before deciding on a course of action. Factors that need to be assessed include credibility of the threat and whether the exposure might result in inhalational anthrax or cutaneous anthrax. Again, the FBI, local law enforcement, local fire departments, and local hazardous materials teams have primary responsibility for determining the credibility of the threat. If these threat response personnel believe that the threat is credible, public health should be consulted to help assess whether the exposure might result in inhalational anthrax or cutaneous anthrax. Credibility An exposure to a substance may be higher risk if: There is a threatening message with the powder or substance The substance is brown or sandy-brown rather than stark white. Of note, the positive NBC letter is reported to have had brownish sand-like material in it. A suspicious letter or package is involved see the CDC Health Alert for details.
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1. Encourage clients who mention sexual problems to talk with their physicians or another trusted health care professional. 2. Reassure them that many people with MS experience sexual problems. 3. Suggest they go to the National MS Society website for more information.
